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A recent study, led by scientists from the University of Colorado Boulder (UCB), suggests an aging gut microbiome may be responsible for the degradation in cardiovascular heath as we grow older. The study is another addition to the growing body of evidenceaffirming the role gut bacteria plays in age-related disease.

Age-related cardiovascular disease is primarily driven by stress-mediated arterial dysfunction. We know that as a human body grows older the risk of cardiovascular disease increases. A striking 70 percent of all people in the United States between the ages of 60 and 79 suffer from some form of cardiovascular disease.

Inspired by the accumulating research pointing to the gut microbiome as a primary modulator of oxidative stress and inflammation, the UCB study looked at whether there was a direct connection between gut bacteria alterations and arterial dysfunction. To examine this, scientists used antibiotics to eliminate the microbiome of both old and young mice. After a few weeks of broad-spectrum antibiotic treatment, the young mice displayed no changes to their arterial health, however, the older mice showed major improvements across several vascular health measures. This suggests that the microorganisms in the aging mice may be responsible for vascular dysfunction.

As we age, the variety of bacteria in our microbiome diminishes. This lack of microbial diversity can result in an imbalance, called dysbiosis, which some hypothesize as the cause of many age-related diseases.  To try to home in on how certain bacteria could be driving cardiovascular disease, the researchers analyzed the differences between the old and young animals’ microbiome.  In the old mice, the researchers saw an increased prevalence of microbes that are pro-inflammatory and have been previously associated with diseases.

Significantly, one particular metabolite appeared in much higher levels in the old mice compared to the younger mice. Trimethylamine N-oxide, or TMAO, is a metabolite that has been strongly linked to atherosclerosis and stroke, and high levels of TMAO can appear in a person’s blood when large volumes of certain bacteria are present in the gut.

Scientists have long known that oxidative stress and inflammation are involved in making arteries unhealthy over time.  It is hypothesized that, with age, the gut microbiota begins producing toxic molecules, including TMAO, which get into the blood stream, cause inflammation and oxidative stress and damage tissue.

It’s too early to jump to any conclusions as to what all this research ultimately means. The researchers suggest that maintaining a diverse microbiome in older age may be a beneficial way to reduce cardiovascular disease risk.  This, of course, is not as simple as eating a particular probiotic, but the researchers are currently investigating the impact of different diets on gut health and cardiovascular disease in human subjects. 

Thanks for reading.

Journal Reference:

Brunt V.E., et al., Suppression of the gut microbiome ameliorates age‐related arterial dysfunction and oxidative stress in mice, The Journal of Physiology, 04 February 2019, https://doi.org/10.1113/JP277336

https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/JP277336

For thousands of years, Chinese has turned to green tea for its mix of health benefits.  Modern studies have reported a myriad of healthy benefit from green tea, including everything from protecting sensitive teethdampening Alzheimer’s symptomsrepelling bacteria and even preventing heart attacks.  Previous studies have also suggested that green tea can be a factor in obesity through its anti-inflammatory effects on gut health, so the researchers at Ohio State University (OHU) drew up some experiments to explore this very idea.

The study took place over 8 weeks and involved a group of male mice, with half of those fed a high-fat diet to induce obesity and the other half fed a normal healthy diet. Within those two groups, half of each had a green tea extract mixed through their food, constituting around two percent of their total diet, or the equivalent to a human drinking 10 cups a day. The scientists say female mice were not included as they are resistant to diet-induced obesity and insulin resistance.

Meanwhile, the researchers measured body weight, fat tissue, insulin resistance, inflammation in the intestines and fat tissue, the makeup of gut microbes, and how the gut bacteria and its derivatives shift into the bloodstream to promote inflammation. This allowed them to tease out a number of useful observations, primarily, that the high-fat mice whose diets were supplemented with green tea gained around 20 percent less weight than those whose were not. These mice also exhibited lower insulin resistance, a factor in the onset of diabetes. 

These green tea-fed mice also featured healthier communities of microbes in the gut and less inflammation in the fat tissue and intestines. They were less prone to leaky gut, where the wall of the small intestines are damaged and allow toxic products to flood into the blood stream.

This study provides evidence that green tea encourages the growth of good gut bacteria, and that leads to a series of benefits that significantly lower the risk of obesity.

It is unclear whether these results will translate to humans, and even if they do, whether we’d be better taking supplements or drinking tea as normal, due to the way the body metabolizes its antioxidants.  However, the lead researcher suggested that consuming a little throughout the course of a day with food, like the mice did in this study, might be better.

Thanks for reading.

Journal Reference:

Dey P. et al., Green tea extract prevents obesity in male mice by alleviating gut dysbiosis in association with improved intestinal barrier function that limits endotoxin translocation and adipose inflammation, The Journal of Nutritional BiochemistryVolume 67, May 2019, Pages 78-89 https://www.sciencedirect.com/science/article/pii/S095528631830723X

Recent aging studies have shown that caloric restriction and fasting have a prolonging effect on lifespan.  A compelling new study by a team of Japanese researchers has offered an incredibly thorough examination into the metabolic alterations that occur in human blood during fasting, revealing a fascinating array of changes that could point to a variety of health benefits.

The research set out to exhaustively analyze the metabolic profile of blood samples as subjects underwent an extensive stretch of fasting. Four healthy participants were recruited and subjected to a long fast, with blood samples taken at three points in the process: 10, 34 and 58 hours after commencing fasting. 

The researchers identified 44 different blood-based metabolites significantly increasing in abundance after 58 hours of fasting.  Alongside known markers signaling the body is moving to utilizing alternative energy stores, such as butyrates and branched-chain amino acids, an interesting increase in anti-oxidant metabolites was found suggesting that the response could be an evolutionary defense against the oxidative stress put on the body during fasting. 

Other previously unidentified metabolites revealed in the study signaled enhanced mitochondrial activity. This discovery adds weight to a compelling Harvard study from last year that suggested that fasting could increase longevity and promote healthy aging by kickstarting youthful plasticity in mitochondrial networks.

Interestingly, three specific metabolites known to be associated with aging and longevity – leucine, isoleucine, and ophthalmic acid – all increased in levels after fasting.  Prior study has revealed these specific metabolites essential for maintenance of muscle and antioxidant activity decrease with age and are found in notably low levels in the elderly. This result suggests the possibility of a rejuvenating effect by fasting.

One of the biggest limitations in this particular study was the small sample size. Although the ultimate increases in metabolites were consistent across all four subjects, how quickly those metabolites peaked did vary from person to person. The researchers note that further work in more subjects will hopefully resolve any questions over individual metabolic respond patterns.

Thanks for reading.

Journal Reference:

Teruya T. et al., Diverse metabolic reactions activated during 58-hr fasting are revealed by non-targeted metabolomic analysis of human blood

Scientific Reports, volume 9, Article Number: 854 (2019)https://www.nature.com/articles/s41598-018-36674-9#Sec10

SEATTLE, Washington – Founded in 2015 to actively promote a healthy lifestyle in San Antonio, San Antonio Running Company (https://sarunningco.com) has become the most recent retail partner for Mocca ShotsâHigh Caffeine Gummies by Seattle Gummy Company (SGC).  

As the last independent running storelocally owned and operated in San Antonio, San Antonio Running Company iscommitted to the local San Antonio running specializing in City and Trail running and Food for Performance.  The company hosts weekly runs that are open to the San Antonio running community, tourists and anyone who wants to improve their health and fitness in a friendly environment.

Acclaimed as an energy product with the highest caffeine concentration available on the market, each Mocca Shotsâdark chocolate gummy packs 100mg of caffeine, the equivalent of a regular cup of coffee.  SGC’s Mocca Shots are unique to the market, bringing consumers flavor, convenience, energy and performance in one powerful gummy. Benefits include:

  • Delicious taste: SGC’s patented technology masks bitterness while bringing out the delicious taste of dark chocolate.
  • Quick absorption, reduced jitters: The caffeine in Mocca Shots™ is absorbed faster than other products via mucosal absorption, and the combination of active ingredients improves focus and alertness while reducing the caffeine jitters.
  • Non-spill convenience: Mocca Shots™ come in a convenient re-sealable pouch with 2 gummies, so you can carry the equivalent of two cups of coffee in your pocket, and they don’t spill.

The caffeine in Mocca Shots™ works 5x faster because ingredients are absorbed through mouth mucosa, by-passing the normal digestive process.  “As a result,” says Dr. Connie Wan, CEO, “next to an IV, Mocca Shots are the fastest way to deliver caffeine directly into the blood stream.” SGC’s Functional Gummy® Delivery System is key to masking caffeine’s unpleasant taste and anxious side effects while improving absorption and bioavailability. This allows you to feel the caffeine kick within minutes of taking the product.

Why Chocolate Gummies? Caffeine increases alertness, focus, cognition and attention but often with jittery side effects. Research shows that caffeine and cocoa together do the same trick but with enhanced focus and reduced anxiety. The combination results in a clean and focused energy without the jittery feeling associated with other caffeinated products. “Feedback we get confirms the science behind Mocca Shots,” says Dr. Connie Wan. “Customers love the clean energy feeling and are amazed at how quickly and effectively Mocca Shots work when they are painfully fatigued or need to be productive.”

Try a sample pack of Mocca Shots High Energy Gummies for just $9.99: https://seattlegummy.com/product/mocca-starter-pack/

About SGC:SGC is a leading developer of gummy pharmaceutical and nutraceuticals. The company specializes in formulating Functional Gummy® products combining the wealth of the in-house knowledge in pharmaceutics, chemistry, western medicine and herbal medicine. The company provides performance gummies® including MOCCA SHOTS™, ENERGON QUBE™, FUNCTIONAL FRUIT®, and SEATTLE BEAUTY®. 

To learn more, visit https://seattlegummy.com, contact[email protected],call 206-257-0464, or join at https://seattlegummy.com/be-an-informed-member/.

A change in diet can reduce the intense pain caused by knee osteoarthritis, the most prominent form of arthritis, according to research findings published this week in the journal Pain Medicine. 

The study conducted at the University of Alabama at Birmingham shows a low-carbohydrate diet was more effective in reducing pain intensity than a low-fat diet in adults ages 65-75 suffering from osteoarthritis.  Researchers found the low-carb diet specifically increased the quality of life and decreased serum levels of the adipokine leptin, a marker of oxidative stress.

The study included 21 adults (nine males, 12 females) who were tested for the efficacy of low-carb and low-fat dietary interventions in pain management in adults ages 65-75 with knee osteoarthritis, the most prominent form of arthritis. This osteoarthritis affects approximately 15 percent of the United States population and, because of its affinity for the lower, weight-bearing joints, has become one of the leading causes of disability in the lower extremities in an ever-aging population.

To test functional pain, researchers asked participants with knee pain to stand from a sitting position a number of times, walk a set distance, and then tested their knees for pain response by repeated stimulation.

Study participants were asked to follow one of the two dietary interventions or continue to eat as normal for a period of 12 weeks. Functional pain, self-reported pain, quality of life and depression were assessed every three weeks. Serum from before and after the diet intervention was analyzed for oxidative stress.

The results showed that the low-carb diet reduced pain intensity and unpleasantness in some functional pain tasks, as well as self-reported pain, especially when compared to the low-fat diet and usual diet participants.  In addition, the low-carb diet also significantly reduced oxidative stress and the adipokine leptin compared with the other diets. That finding was particularly interesting since reduction in oxidative stress was related to reduced functional pain, or pain associated with engaging in normal, everyday things.  

Many medications for pain cause a host of side effects that may require other drugs to reduce.  Because there is no curative treatment for knee osteoarthritis outside of a knee replacement, persistent pain is commonly treated with opioids, acetaminophen and nonsteroidal anti-inflammatory drugs — all of which have unpleasant side effects if used for an extensive period.  Over-the-counter anti-inflammatory medication side effects can include high blood pressure, liver or kidney problems, stomach ulcers and pain, heartburn, allergic reactions such as rashes, wheezing and throat swelling, and a tendency to bleed more, especially when taking aspirin.

The advantage of a change in diet is that it can be done without long-term anti-inflammatory use or prescription medications, and it can be tailored to taste and preferences.

Interestingly, the researcher noted that weight loss alone did not reduce pain in study participants.  In fact, the quality of the diet and types of foods consumed have more to do with pain reduction than weight loss, according to our findings. Diets such as the Mediterranean diet (a partial low-carbohydrate diet) have been shown to reduce inflammation in arthritis patients and self-reported pain in osteoarthritis and rheumatoid arthritis. This work supported the hypothesis that, by lowering the intake of refined carbohydrates, oxidative stress would decrease and functional pain would be improved.

Thanks for reading.

Journal Reference:

Strath, L.J. et. al, The Effect of Low-Carbohydrate and Low-Fat Diets on Pain in Individuals with Knee Osteoarthritis, Pain Medicine, pnz022, https://doi.org/10.1093/pm/pnz022(March 13, 2019)

The benefit of exercising on cardiovascular and brain health are well known and well researched.  How about aging, you may wonder, would exercise slow down the aging process?  The answer is yes according to a recent study by researchers at the University of Birmingham and King’s College London, which has found that staying active keeps the body young and healthy.

The researchers set out to assess the health of older adults who had exercised most of their adult lives to see if this could slow down ageing. The study recruited 125 amateur cyclists aged 55 to 79, 84 of which were male and 41 were female. The men had to be able to cycle 100 km in under 6.5 hours, while the women had to be able to cycle 60 km in 5.5 hours. Smokers, heavy drinkers and those with high blood pressure or other health conditions were excluded from the study.

The participants underwent a series of tests in the laboratory and were compared to a group of adults who do not partake in regular physical activity. This group consisted of 75 healthy people aged 57 to 80 and 55 healthy young adults aged 20 to 36.

The study showed that loss of muscle mass and strength did not occur in those who exercise regularly. Furthermore, the cyclists did not increase their body fat or cholesterol levels with age and the men’s testosterone levels remained high, suggesting that they may have avoided most of the male menopause.

More surprisingly, the study revealed that the benefits of exercise extend beyond muscle.  Specifically, researchers have found that the cyclists had an immune system that did not seem to have aged.  An organ called the thymus, which makes immune cells called T cells, starts to shrink from the age of 20 and makes less T cells.  T cells are our body’s natural defense against infections.  Reduced T cells population in old age is one of the reasons for the increased tendency to become ill as we age.  In this study, however, the cyclists’ thymuses were making as many T cells as those of a young person.

The research means that committing to regular exercise throughout a lifetime is a viable solution to the problem that we are living longer but not healthier. Through regular exercise, our bodies could age optimally, free from the problems usually caused by inactivity.

The take home lesson is that finding an exercise that you enjoy in whatever environment that suits you and make a habit of physical activity. You will reap the rewards of being vibrant, productive, independent, and looking fabulous throughout your life.

Thanks for reading.

Journal References:

  1. Ross D. Pollock, Katie A. O’Brien, Lorna J. Daniels, Kathrine B. Nielsen, Anthea Rowlerson, Niharika A. Duggal, Norman R. Lazarus, Janet M. Lord, Andrew Philp, Stephen D. R. Harridge. Properties of the vastus lateralis muscle in relation to age and physiological function in master cyclists aged 55-79 years. Aging Cell, 2018; e12735 DOI: 1111/acel.12735

Duggal et al. Major features of Immunesenescence, including Thymic atrophy, are ameliorated by high levels of physical activity in adulthood. Aging Cell, 2018

SEATTLE, Washington – Started in early 2000s to promote and serving running community in Baltimore, Charm City Run (http://www.charmcityrun.com) has become the most recent retail partner for Mocca ShotsâHigh Caffeine Gummies by Seattle Gummy Company (SGC).  

With a goal to create a place where people would want to hang out and create a workplace where people would want to work, Josh and Kara Levinson opened Charm City Run in Baltimore after moving back from Texas with a determination to serve local communities with customer service second-to-none.  The store now regularly organizes running events and helps to raise funds for local non-profits.

Acclaimed as an energy product with the highest caffeine concentration available on the market, each Mocca Shotsâdark chocolate gummy packs 100mg of caffeine, the equivalent of a regular cup of coffee.  SGC’s Mocca Shots are unique to the market, bringing consumers flavor, convenience, energy and performance in one powerful gummy. Benefits include:

  • Delicious taste: SGC’s patented technology masks bitterness while bringing out the delicious taste of dark chocolate.
  • Quick absorption, reduced jitters: The caffeine in Mocca Shots™ is absorbed faster than other products via mucosal absorption, and the combination of active ingredients improves focus and alertness while reducing the caffeine jitters.
  • Non-spill convenience: Mocca Shots™ come in a convenient re-sealable pouch with 2 gummies, so you can carry the equivalent of two cups of coffee in your pocket, and they don’t spill.

The caffeine in Mocca Shots™ works 5x faster because ingredients are absorbed through mouth mucosa, by-passing the normal digestive process.  “As a result,” says Dr. Connie Wan, CEO, “next to an IV, Mocca Shots are the fastest way to deliver caffeine directly into the blood stream.” SGC’s Functional Gummy® Delivery System is key to masking caffeine’s unpleasant taste and anxious side effects while improving absorption and bioavailability. This allows you to feel the caffeine kick within minutes of taking the product.

Why Chocolate Gummies? Caffeine increases alertness, focus, cognition and attention but often with jittery side effects. Research shows that caffeine and cocoa together do the same trick but with enhanced focus and reduced anxiety. The combination results in a clean and focused energy without the jittery feeling associated with other caffeinated products. “Feedback we get confirms the science behind Mocca Shots,” says Dr. Connie Wan. “Customers love the clean energy feeling and are amazed at how quickly and effectively Mocca Shots work when they are painfully fatigued or need to be productive.”

Try a sample pack of Mocca Shots High Energy Gummies for just $9.99: https://seattlegummy.com/product/mocca-starter-pack/

About SGC:SGC is a leading developer of gummy pharmaceutical and nutraceuticals. The company specializes in formulating Functional Gummy® products combining the wealth of the in-house knowledge in pharmaceutics, chemistry, western medicine and herbal medicine. The company provides performance gummies® including MOCCA SHOTS™, ENERGON QUBE™, FUNCTIONAL FRUIT®, and SEATTLE BEAUTY®. 

To learn more, visit https://seattlegummy.com, contact[email protected],call 206-257-0464, or join at https://seattlegummy.com/be-an-informed-member/.

SEATTLE, Washington − Seattle Gummy Company (SGC), a Seattle Washington based nutraceutical and pharmaceutical company focusing on functional gummy formulations, has received an investment from a Hong Kong based private equity fund, closing up the company’s series A financing.  Ms. Jane Cui is joining the SGC’s Board of Directors representing the newest investor.

Currently serving as the President of Leica Camera Asia, Jane is extensively connected in the tech corporate world.  Recognized as one of the top sales executives in Microsoft, Jane possesses extensive sales marketing experience accumulated in various management positions at Microsoft, including as the General Manager of Microsoft Corporation.  Jane will be helping to guide SGC’s sales, marketing as well as business development strategies.

SGC has been raising fund to aggressively expand its gummy pharmaceutical products pipeline as well as its extensive intellectual property holdings in the gummy nutraceutcial and pharmaceutical space.  This newest investment will help to accelerate the company’s gummy drug development program and further expand the sales of its all-natural, vegan and non-GMO performance gummy product lines.

Built upon its proprietary Functional Gummy® technology platform, SGC is currently marketing several performance gummy products including MOCCA SHOT, a highest concentrated caffeine product on the market. “We feel very honored and fortunate to have Jane joining the board.” Commented Dr. Connie Wan, the Company CEO, “With Jane’s expertise in sales and marketing as well as the strategic advice and international connections, we are confident that SGC will achieve a huge success both domestically and internationally.”

About Seattle Gummy Company (SGC): SGC is an R&D focused developer and manufacturer of nutraceutical and pharmaceutical gummy products. The company specializes in formulating Functional Gummy® products combining the wealth of the in-house knowledge in pharmaceutics, organic chemistry, natural product chemistry, modern medicine, and herbal medicine.  The company provides performance gummy that fit to each customer’s unique life style.  The current performance gummy product line includes MOCCA SHOTS®, ENERGON QUBE™, FUNTIONAL FRUIT®, and SEATTLE BEAUTY®. To learn more about SGC, visit https://seattlegummy.com.

SEATTLE, Washington – Mocca Shots High Caffeine Gummies by Seattle Gummy Company (SGC) are now available on campuses in four universities:

Acclaimed as an energy product with the highest caffeine concentration available on the market, each Mocca Shots dark chocolate gummy packs 100mg of caffeine, the equivalent of a regular cup of coffee.  SGC’s Mocca Shots are unique to the market with is all natural, non-GMO and vegan ingredients, bringing college students performance, convenience and flavor in one powerful gummy.  Benefits include:

  • Quick absorption, reduced jitters:The caffeine in Mocca Shots™ is absorbed faster than other products via mucosal absorption, and the combination of active ingredients improves focus and alertness while reducing the caffeine jitters.
  • Delicious taste:SGC’s patented technology masks bitterness while bringing out the delicious taste of dark chocolate.
  • Non-spill convenience:Mocca Shots™ come in a convenient resealable pouch with 2 gummies, so you can carry the equivalent of two cups of coffee in your pocket, and they don’t spill.

The caffeine in Mocca Shots™ works 5x faster because ingredients are absorbed through mouth mucosa, by-passing the normal digestive process. “As a result,” says Dr. Connie Wan, CEO, “next to an IV, Mocca Shots are the fastest way to deliver caffeine directly into the blood stream.” SGC’s Functional Gummy® Delivery System is key to masking caffeine’s unpleasant taste and anxious side-effects while improving absorption and bioavailability. This allows you to feel the caffeine kick within minutes of taking the product.

Why Chocolate Gummies? Caffeine increases alertness, focus, cognition and attention but often with jittery side-effects. Research shows that caffeine and cocoa together do the same trick but with enhanced focus and reduced anxiety. The combination results in a clean and focused energy without the jittery feeling associated with other caffeinated products. “Feedback we get confirms the science behind Mocca Shots,” says Dr. Connie Wan. “Customers love the clean energy feeling and are amazed at how quickly and effectively Mocca Shots work when they are painfully fatigued or need to be productive.  For students, Mocca Shots helps with the focus without the jittery side effect from traditional junk-filled energy drinks, and” Dr. Connie Wan then added, “nor the needs to go to the bathroom in the middle of the exam.”

Try a sample pack of Mocca Shots High Energy Gummies for just $9.99:  https://seattlegummy.com/product/mocca-starter-pack/

About SGC:SGC is an R&D focused developer of nutraceutical and pharmaceutical gummy products. The company specializes in formulating Functional Gummy® products combining the wealth of the in-house knowledge in pharmaceutics, chemistry, western medicine and herbal medicine. The company provides performance gummies® inspired by Traditional Chinese Medicine including MOCCA SHOTS™, ENERGON QUBE™, FUNCTIONAL FRUIT®, and SEATTLE BEAUTY®.

To learn more, visit https://seattlegummy.com, [email protected],call 206-257-0464, or join at https://seattlegummy.com/be-an-informed-member/.

 

Large volume of recent researches has shown that low-grade systemic inflammation leads to metabolic diseases ranging from cardiovascular diseases, type 2 diabetes, obesity, dementia, chronicle pain, and aging.  Other than medications, stopping inflammation should start with an everyday anti-inflammatory (AI) diet.  Benefits of a healthy AI diet include the reduced risks of heart diseases and cancers, reduced incidences of autoimmune diseases, weight loss, improved insulin sensitivity, and slowed aging process in general.

A healthy AI diet should include a balance of nutrient-dense foods such as protein, carbohydrates and fat with lots of vegetables and limited amount of fruits.  Stick with a few basics when creating on your own AI diet:

  • Eat low-fat protein such as lean meat and beans;
  • Eat whole grains and avoid refined carbohydrates;
  • Eat omega-3 rich food such as nuts, flaxseed and fish;
  • Eat antioxidant rich food such as cruciferous vegetables, tomatoes, artichokes, leafy greens, peppers, deep-colored fruits, sweet potato, dark chocolate, coffee, and tea;
  • Incorporate anti-inflammatory herb into your diet such as ginger (which you could find in SGC’s Energon Qube Recover product), turmeric (which you could find in SGC’s Golden Glow product) and garlic;
  • Reduce omega-6 fatty acids intake such as margarine and vegetable oils such as corn, soybean, and canola; and
  • Avoid trans mono-saturated fatty acid (meaning processed food).

The AI diet is neither a magic panacea nor a quick-fix treatment.  However, long-term consumption of an AI diet offers steady health improvement. With so many AI food options that are available, following an AI diet is not difficult.  Stick to it, you will see the improvement on your general well being.

Thanks for reading.

Dr. Connie Wan